Pair Name	Beta-Elemene, Bevacizumab
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	MKI67	hsa4288
	Down-regulation	Expression	PECAM1	hsa5175
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vivo Model	HCT-116 cells in the logarithmic growth phase were selected and suspended in PBS after 0.25% pancreatic enzyme digestion (cell concentration: 1×10⁷/mL, living cells >95% after trypan blue staining). Nude mice were intraperitoneally injected with 0.2 mL of the cell suspension (total, 2×106 cells/mice) in the right axilla.
Result	Bevacizumab exerts a synergistic effect with β-elemene in suppressing the growth of tumors derived from HCT-116 cells, and the related mechanisms may include the inhibition of tumor cell proliferation and tumor angiogenesis and the promotion of tumor cell apoptosis.